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TRPM7 channel mediate ferroptosis in RA chondrocytes through regulating PKCα-NOX4 axis. System Xc− inhibition and GSH depletion-mediated TRPM7 upregulation triggers PKCα activation via direct binding with NOX4 domain, thus aggravating the accumulation of ROS and lipid peroxidation, and eventually leading to ferroptosis in RA chondrocytes (Created with BioRender.com).
