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. 2022 Jul 19;9:923377. doi: 10.3389/fnut.2022.923377

Figure 1.

Figure 1

High-fat diet and high-sucrose intake caused divergent changes in metabolism in mice. Male C57BL/6J mice (4 weeks old) were, respectively, treated with chow diet (Con), high-sucrose diet (HSD), or high-fat diet (HFD) for 4, 8, and 12 weeks. (A) Body weight and tissue distribution, including liver, white adipose tissue (WAT), and brown adipose tissue (BAT) (g). (B) Average energy intake per mouse (kcal/day). (C) WAT, BAT, and liver index (index=tissue weight/body weight). (D) Serum triglyceride (TG) level (mmol/L). (E) Serum non-esterified fatty acid (NEFA) level (mmol/L). (F) Serum high-density lipoprotein cholesterol (HDL-C) level (mmol/L). (G) Serum low-density lipoprotein cholesterol (LDL-C) level (mmol/L). (H) Representative photomicrographs of liver tissue with H&E staining (magnification, ×200, 50 μm), with corresponding hepatic steatosis scores. (I) Serum total cholesterol (TC) level (mmol/L). (J) Hepatic TG level (mmol/g liver). (K) Serum ALT level (U/L). Data are represented as the mean ± SEM. N = 10–15; *p < 0.05, **p < 0.01, ***p < 0.001 (HSD vs. Con, except plot A); #p < 0.05, ##p < 0.01, ###p < 0.001 (HFD vs. Con); &p < 0.05, &&p < 0.01, &&&p < 0.001 (HFD vs. HSD).