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. 2022 Jul 19;9:923377. doi: 10.3389/fnut.2022.923377

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Copyright © 2022 Zhu, Hong, Li, Li, Zhong, He, Zheng, Sheng and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High-fat diet changed the main functions of gut dysbiosis in mice. Microbial functions regulated by HFD or HSD were predicted with PICRUSt2. (A) Heatmap summarizing the changes in gut microbial community function at KEGG level 2, following Con, HSD, and HFD group at three time point in mice. Black circle represents the KEGG pathway which was significantly altered relative to Con or HSD groups at same time point (p < 0.05). (B) Relative abundance of the pathways related to glycolipid metabolism disorder. Data are represented as the mean ± SEM. n = 4-5; *p < 0.05, **p < 0.01, ***p < 0.001 (HSD vs. Con); ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 (HFD vs. Con); ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001 (HFD vs. HSD).