Figure 8.

High-fat diet and high-sucrose intake differently altered the hepatic transcriptomic profile. RNA-seq was performed on liver tissues in mice fed with Con, HSD, and HFD for 12 weeks. (A) Principal component analysis (PCA) and sample clustering tree among groups. (B) Experimental strategy of the genetic screenings. (C) KEGG pathway enrichment analysis on the differential gene between HSD and Con. (D) KEGG pathway enrichment analysis on the differential gene between HFD and Con. Common pathways were shown on the left, and uniport pathways were shown on the right, in plot D and E. (E) Heatmap of genes from lipid metabolism pathway.