FIGURE 2.

Microglia/macrophage transcription pathways that modulate phagocytosis following brain injuries. STAT6 signaling pathways might be modulated by IL‐4/IL‐13 or IL‐33, thereby modifying the phagocytic ability of microglia/macrophages. The STAT6 pathway also interacts with PPARγ and enhances microglia/macrophage phagocytosis in ischemic stroke. PPARγ, Nrf2, and HIF‐1α/β signaling induce expression of CD36 on the cell surface of microglia/macrophages, while HIF‐1α/β signaling may increase cell surface presentation of MFG‐E8 and magnify the phagocytic capability of microglia/macrophages following stroke