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. 2022 Jul 14;13:931153. doi: 10.3389/fimmu.2022.931153

Figure 3.

Figure 3

Evolution of pulmonary function and chest CT over time. (A) Pulmonary function. (B) Chest CT. Evolution of pulmonary function over time in relation to lung transplantation (LTx) and allogeneic hematopoietic stem cell (Allo-HCT) for hereditary pulmonary alveolar proteinosis (A), which are indicated by dotted lines. Dots represent individual measurements of lung volumes (Liters), with connecting lines between measurements showing the trend of individual lung function parameters over time. Evolution of chest computed tomography (CT) function over time (B), with representative inspiratory phase images at 3 months, 6 months 1 year and 4 years post-lung transplantation (LTx). Allogeneic hematopoietic stem cell (Allo-HCT) was performed 11 months after prior lung transplantation. At 4.5 years after lung transplantation there is currently no evidence for chronic lung allograft dysfunction, graft-versus-host disease, or recurrence of hereditary pulmonary alveolar proteinosis. FVC, forced vital capacity; FEV1, forced expiratory volume in one second; FEF25-75, forced expiratory flow at 25–75% of forced vital capacity; TLC, total lung capacity; TLCO, transfer capacity of the lung, for the uptake of carbon monoxide (CO) (also called diffusing capacity for carbon monoxide).