Table 3.
Correlation between Single or Multiple Unfavorable Histologic Features and Risk of LN Metastasis in Early Colorectal Cancer
| Histologic features | Suh et al. (2012) [63] | Yasue et al. (2019) [64] | ||
|---|---|---|---|---|
| No. | LN metastasis, No. (%) | No. | LN metastasis, No. (%) | |
| [1] Depth of invasion > 1 mm or sm2/sm3 | 118 | 2 (1.7) | 258 | 4 (1.6) |
| [2] Lymphovascular invasion | 43 | 9(20.9) | 20 | 3 (15.0) |
| [3] Poor differentiation | 1 | 0 | 3 | 0 |
| [4] Tumor budding grade 2/3 | NA | NA | 1 | 0 |
| [1] + [2] | 100 | 22(22.0) | 189 | 24 (12.7) |
| [2] + [3] | 1 | 1 (100) | 1 | 0 |
| [1] + [3] | 1 | 1 (100) | 15 | 1 (6.3) |
| [1] + [4] | NA | NA | 40 | 3 (7.5) |
| [2] + [4] | NA | NA | 1 | 0 |
| [3] + [4] | NA | NA | 1 | 0 |
| [1] + [2] + [3] | 7 | 5(71.4) | 17 | 5 (29.4) |
| [1] + [2] + [3] + [4] | NA | NA | 44 | 15 (34.1) |
LN, lymph node; NA, not available.