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. Author manuscript; available in PMC: 2022 Aug 2.
Published in final edited form as: J Psychiatr Res. 2016 Jul 11;82:1–7. doi: 10.1016/j.jpsychires.2016.07.006

Table 3.

Biological processes and pathways related to the differentially expressed proteins in late life major depression.

Biological pathways and processes DE in set DE not in set NonDE in set NonDE not in set Match gene p-value-permute q-value-permute
Go MF protein dimerization activity 10 39 171 10 134 AMBP/APOA2/APOA4/APOB/APOE/CST3/EGFR/ERBB2/IL12B/VWF 0.000999001 0.0834165834
Go MF protein homodimerization activity 6 43 114 10 191 AMBP/APOA2/APOA4/APOE/CST3/VWF 0.000999001 0.0834165834
Go BP protein secretion 5 44 27 10 278 ANG/APOA1/APOA2/INS/PPY 0.002997003 0.1251248751
Go MF protein heterodimerization activity 6 43 71 10 234 APOA2/APOB/APOE/EGFR/ERBB2/IL12B 0.002997003 0.1251248751
Go BP lipid homeostasis 4 45 12 10,293 APOA1/APOA2/APOA4/APOE 0.004995005 0.1429998573
Reactome chylomicron mediated lipid transport 5 44 12 10,293 APOA1/APOA2/APOA4/APOB/APOE 0.005994006 0.1429998573
Go BP regulation of hydrolase activity 3 46 72 10,233 ANG/APOA2/EGFR 0.005994006 0.1429998573
Go BP establishment of protein localization 6 43 178 10,127 ANG/APOA1/APOA2/INS/EGFR/PPY 0.006993007 0.145979021
Reactome lipoprotein metabolism 5 44 22 10,283 APOA1/APOA2/APOA4/APOB/APOE 0.008991009 0.1668331668
Go MF phospholipid binding 3 46 38 10,267 APOA1/APOA4/APOE 0.011988012 0.1787498216
Go BP regulation of protein secretion 4 45 18 10,287 ANG/APOA1/APOA2/INS 0.012987013 0.1787498216
Go BP regulation of secretion 4 45 36 10,269 ANG/APOA1/APOA2/INS 0.012987013 0.1787498216
Go BP lipoprotein metabolic process 3 46 30 10,275 APOA1/APOA2/APOA4 0.013986014 0.1787498216
Go BP lipid transport 4 45 24 10,281 APOA1/APOA2/APOA4/APOE 0.014985015 0.1787498216
Go MF peptide binding 2 47 80 10,225 ANG/MSLN 0.021978022 0.2446886447
Go BP Secretion by cell 5 44 109 10,196 ANG/APOA1/APOA2/INS/PPY 0.035964036 0.2678111362
Go BP cytokine secretion 3 46 15 10,290 APOA1/APOA2/INS 0.036963037 0.2678111362
Biocarta ppara pathway 4 45 54 10,251 APOA1/APOA2/INS/FABP1 0.037962038 0.2678111362
Go CC cytoplasmic membrane bound vesicle 3 46 109 10,196 APOA1/EGFR/VWF 0.037962038 0.2678111362
Go CC membrane bound vesicle 3 46 111 10,194 APOA1/EGFR/VWF 0.037962038 0.2678111362
Go BP phospholipase c activation 2 47 9 10,296 ANG/EGFR 0.038961039 0.2678111362
Go BP Positive regulation of hydrolase activity 2 47 49 10,256 ANG/EGFR 0.038961039 0.2678111362
Go BP G protein signaling coupled to IP3 second messenger/PLC activating 2 47 39 10,266 ANG/EGFR 0.040959041 0.2678111362
Go BP phosphoinositide mediated signaling 2 47 42 10,263 ANG/EGFR 0.040959041 0.2678111362
Go BP regulation of cytokine secretion 3 46 13 10,292 APOA1/APOA2/INS 0.041958042 0.2678111362
Go BP regulation of protein stability 2 47 17 10,288 APOA1/APOA2 0.041958042 0.2678111362
Go BP lipid biosynthetic process 3 46 94 10,211 ANG/APOA1/MIF 0.044955045 0.2678111362
Go BP lipoprotein biosynthetic process 2 47 24 10,281 APOA1/APOA2 0.047952048 0.2678111362
Go MF protein complex binding 3 46 51 10,254 AMBP/INS/VWF 0.048951049 0.2678111362
Go BP negative regulation of secretion 2 47 11 10,294 APOA1/APOA2 0.04995005 0.2678111362
Go CC extracellular matrix part 2 47 55 10,250 ANG/COL18A1 0.04995005 0.2678111362