Table 1.
Patient baseline demographics and disease characteristics (FAS)
| Treatment-naïve (n = 181) |
Previously treated (n = 77) |
Overall (n = 258) |
|
|---|---|---|---|
| Age, years, mean ± SD | 64.6 ± 9.8 | 63.0 ± 8.6 | 64.1 ± 9.5 |
| Female | 70 (38.7) | 43 (55.8) | 113 (43.8) |
| Country | |||
| Argentina | 111 (61.3) | 25 (32.5) | 136 (52.7) |
| Colombia | 11 (6.1) | 7 (9.1) | 18 (7.0) |
| Costa Rica | 3 (1.7) | 6 (7.8) | 9 (3.5) |
| Mexico | 56 (30.9) | 39 (50.7) | 95 (36.8) |
| Diabetes mellitus | |||
| Type 1 | 18 (9.9) | 0 | 18 (7.0) |
| Type 2 | 163 (90.1) | 77 (100) | 240 (93.0) |
| Severity of diabetic retinopathy | |||
| Mild | 26 (14.4) | 10 (13.0) | 36 (14.0) |
| Moderate | 66 (36.5) | 23 (29.9) | 89 (34.5) |
| Severe | 76 (42.0) | 40 (52.0) | 116 (45.0) |
| Missing | 13 (7.2) | 4 (5.2) | 17 (6.6) |
| Comorbiditiesa | |||
| Hypertension | 76 (42.0) | 52 (67.5) | 128 (49.6) |
| Cataracts | 34 (18.8) | 19 (24.7) | 53 (20.5) |
| Hyperlipidemia | 18 (9.9) | 7 (9.1) | 25 (9.7) |
| Obesity | 8 (4.4) | 11 (14.3) | 19 (7.4) |
| BCVA in the study eye, mean ± SD letter score | 54.5 ± 19.4 | 52.9 ± 18.6 | 54.0 ± 19.2 |
| Categorical BCVA letter score, n (%) | |||
| ≥ 70 letters (≥ 20/40 Snellen) | 50 (27.6) | 17 (22.1) | 67 (26.0) |
| < 70 letters (< 20/40 Snellen) | 131 (72.4) | 60 (77.9) | 191 (74.0) |
| CRT, μm, mean ± SD | 388 ± 145 | 423 ± 146 | 398 ± 146 |
BCVA best-corrected visual acuity, CRT central retinal thickness, FAS full analysis set, SD standard deviation
aReported in ≥ 5% of patients. Values are n (%) unless otherwise stated