TABLE 2.

Environmental and genetic regulation of S. typhimurium ivi genes

Strain	Gene	Function	Environmental signal(s)	PhoPQ regulation	Parameters	Reference(s)a
MT1371	phoP	Virulence regulator	pH + Mg2+	pag	i.g., i.p./spleenb	16, 23, 38, 40, this work
MT1698	pmrB	Polymyxin resistance	pH + Mg2+	pag	Cultured macrophage	21, 23, 39, this work
MT1701	spvB	Plasmid virulence	pH + Mg2+	pag	i.p./spleen	13, 23, this work
MT1228	mgtA	Mg2+ transport	pH + Mg2+	pag	i.p./spleen; cultured macrophage	16, 23, 39, 40, this work
MT1695	mgtB	Mg2+ transport	pH + Mg2+	pag	i.p./spleen	15, 16, 23, 40, 41, this work
MT1704	iviVI-A	Adhesin-like	pH + Mg2+	pag	i.p./spleen	23, this work
MT1818	iviXVI	Aldehyde dehydrogenase-like	pH + Mg2+	pag	i.p./spleen	This work
MT1819	iviXVII (pdu)	1,2-Propanediol utilization	pH + Mg2+, iron O2, propanediol	prg	i.p./spleen	1, 5, this work
MT1772	fhuA	Iron transport	Iron	None	i.g./small intestine	23, 41, this work
MT1833	cirA	Colicin 1 receptor	Iron	None	Cultured macrophage	23, this work
MT1801	entF	Enterobactin synthesis	Iron	None	Cultured macrophage	23, this work

^aListed are references relevant to environmental signals that affect ivi gene expression in S. typhimurium. 

^bRoute of delivery (intragastric [i.g.] or intraperitoneal [i.p.])/host tissue from which bacteria were recovered.