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. 2022 Jun 16;13:874815. doi: 10.3389/fendo.2022.874815

Table 2.

Univariate analysis for BCSS in MBC patients.

Variables Befor PSM After PSM
HRs 95% CI P HRs 95% CI P
Age group
 ≤ 60 years 1 [Reference] 1 [Reference]
 > 60 years 1.318 1.048-1.657 0.018 1.142 0.651-2.006 0.643
Race/ethnicity (n, %)
 White 1 [Reference] 1 [Reference]
 Black 1.395 1.063-1.831 0.017 1.072 0.520-2.210 0.850
 Other 0.921 0.129-6.567 0.935
Insurance (n, %)
 No 1 [Reference] 1 [Reference]
 Yes 0.684 0.496-0.847 0.001 0.483 0.263-0.887 0.019
Grade (n, %)
 Undifferentiated 1 [Reference] 1 [Reference]
 Poorly differentiated 0.774 0.433-1.382 0.387 1.427 0.196-10.361 0.725
 Moderately differentiated 0.386 0.190-0.784 0.008 0.674 0.061-7.436 0.748
 Well differentiated 0.284 0.107-0.758 0.012 0.876 0.055-14.013 0.925
 Unknown 0.692 0.358-1.341 0.276 0.616 0.039-9.851 0.732
Histology (n, %)
 Metaplastic carcinoma 1 [Reference] 1 [Reference]
 Adenosquamous carcinoma 0.211 0.079-0.567 0.002 0.567 0.175-1.832 0.343
 Carcinosarcoma 1.637 1.079-2.484 0.021 2.440 0.964-6.177 0.060
 Others 0.765 0.341-1.718 0.517
Tumor size (n, %)
 T1 1 [Reference] 1 [Reference]
 T2 2.273 1.519-3.401 <0.001 1.375 0.560-3.372 0.487
 T3 7.795 5.177-11.736 <0.001 4.300 1.713-10.790 0.002
 T4 13.221 8.591-20.346 <0.001 17.252 6.688-44.503 < 0.001
 Unknown 2.219 0.303-16.274 0.433 3.794 0.466-30.863 0.212
Lymph node state
 N0 1 [Reference] 1 [Reference]
 N1 1.846 1.340-2.544 <0.001 2.110 1.023-4.355 0.043
 N2 1.993 1.204-3.299 0.007 3.978 1.506-10.507 0.005
 N3 1.576 1.090-2.279 0.016 3.288 1.592-6.792 0.001
TNM stage (n, %)
 I 1 [Reference] 1 [Reference]
 II 3.089 1.990-4.795 <0.001 1.326 0.519-3.390 0.555
 III 10.396 6.600-16.376 <0.001 6.260 2.447-16.015 <0.001
 IV 34.276 20.439-57.479 <0.001 23.360 8.138-67.058 <0.001
 Unknown 1.616 0.218-11.969 0.638 4.069 0.489-33.840 0.194
ER status
 negative 1 [Reference] 1 [Reference]
 positive 0.787 0.588-1.053 0.107 0.420 0.179-0.987 0.047
HER2 status
 negative 1 [Reference] 1 [Reference]
 positive 0.784 0.487-1.262 0.316 0.584 0.327-1.044 0.069
PMRT
 No 1 [Reference] 1 [Reference]
 Yes 0.727 0.579-0.913 0.006 0.370 0.196-0.697 0.002
PMCT
 No 1 [Reference] 1 [Reference]
 Yes 0.904 0.718-1.139 0.393 0.754 0.376-1.511 0.426

MBC, metaplastic breast cancer; PSM, propensity score-matching; ER, estrogen receptor; HER2, Human epidermal growth factor receptor 2; PMRT, post-mastectomy radiotherapy; PMCT, post-mastectomy chemotherapy; BCSS, Breast cancer-specific survival; HRs, Hazard ratios; CI, Confidence interval.