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. 2022 Aug 2;20:344. doi: 10.1186/s12967-022-03558-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Dose–response using restricted cubic spline model for the association between total fiber intake and mortality from all causes (A), cardiovascular disease (B) and cancer (C). Solid line represents point estimates and dashed lines represent 95% confidence intervals. Multivariable risk estimate was calculated by restricted cubic spline regression (using 3 knots at 10th, 50th, and 90th percentiles) adjusting for age, sex, race, body mass index, education, smoking status, marital status, alcohol drinking status, and total energy intake. The histograms show the percentage of participants (left y axis) consuming each level of fiber