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. 2022 Aug 2;20:344. doi: 10.1186/s12967-022-03558-6

Table 2.

Association between dietary fiber intake and all-cause mortality

Variables Median (g/day) Cohort (n) Cases (n) Crude HR (95% CI), p-value Adjusted HR* (95% CI), p-value
Total
 Q1 (< 11.12) 8.83 17,360 3852 Reference Reference
 Q2 (≥ 11.12 to < 14.71) 12.95 17,330 3515 0.88 (0.84–0.93), p < 0.001 0.88 (0.84–0.92), p < 0.001
 Q3 (≥ 14.71 to < 18.41) 16.48 17,322 3380 0.83 (0.79–0.87), p < 0.001 0.82 (0.78–0.86), p < 0.001
 Q4 (≥ 18.41 to < 23.75) 20.74 17,304 3348 0.82 (0.78–0.85), p < 0.001 0.77 (0.73–0.82), p < 0.001
 Q5 (≥ 23.75) 28.75 17,326 3441 0.83 (0.79–0.87), p < 0.001 0.71 (0.66–0.75), p < 0.001
p for trend < 0.001 p for trend < 0.001
Insoluble
 Q1 (< 7.21) 5.7 17,366 3871 Reference Reference
 Q2 (≥ 7.21 to < 9.63) 8.44 17,342 3554 0.89 (0.85–0.93), p < 0.001 0.89 (0.85–0.93), p < 0.001
 Q3 (≥ 9.63 to < 12.11) 10.8 17,312 3361 0.82 (0.78–0.86), p < 0.001 0.82 (0.78–0.86), p < 0.001
 Q4 (≥ 12.11 to < 15.73) 13.69 17,332 3318 0.80 (0.77–0.84), p < 0.001 0.77 (0.73–0.81), p < 0.001
 Q5 (≥ 15.73) 19.09 17,290 3432 0.82 (0.78–0.86), p < 0.001 0.71 (0.67–0.75), p < 0.001
p for trend < 0.001 p for trend < 0.001
Soluble fiber
 Q1 (< 3.72) 2.97 17,395 3817 Reference Reference
 Q2 (≥ 3.72 to < 4.91) 4.32 17,304 3477 0.89 (0.85–0.93), p < 0.001 0.89 (0.85–0.93), p < 0.001
 Q3 (≥ 4.91 to < 6.15) 5.49 17,351 3404 0.85 (0.81–0.89), p < 0.001 0.84 (0.80–0.88), p < 0.001
 Q4 (≥ 6.15 to < 7.92) 6.91 17,266 3290 0.81 (0.77–0.85), p < 0.001 0.77 (0.73–0.81), p < 0.001
 Q5 (≥ 7.92) 9.62 17,326 3548 0.87 (0.83–0.91), p < 0.001 0.76 (0.71–0.81), p < 0.001
p for trend < 0.001 p for trend < 0.001

*Adjusted for age (continuous), sex (male vs. female), race (non-Hispanic White vs. Other), body mass index (BMI, < 25.0 kg/m2 vs. ≥ 25.0 kg/m2), education (≤ high school vs. ≥ some college), smoking status (never vs. former ≤ 15 years since quit vs. former > 15 years since quit vs. former year since quit unknown vs. current smoker ≤ 1 pack per day vs. current smoker > 1 pack per day vs. current smoker intensity unknown), marital status (married vs. not married), alcohol drinking status (never vs. former vs. current), and total energy intake (continuous)