Table 3.
Top 20 biologic pathways by rank sum across both cohorts and tissues
| Biologic pathway | MARBLES cord rank | MARBLES placenta rank | EARLI cord rank | EARLI placenta rank | Rank sum |
|---|---|---|---|---|---|
| Behavior | 33 | 29 | 41 | 137 | 240 |
| Nervous system development | 718 | 8 | 1 | 8 | 735 |
| Axon development | 255 | 282 | 368 | 13 | 918 |
| Regulation of synaptic plasticity | 116 | 313 | 122 | 434 | 985 |
| Synapse organization | 760 | 25 | 285 | 42 | 1112 |
| Neurogenesis | 1125 | 5 | 18 | 32 | 1180 |
| Cell morphogenesis involved in differentiation | 424 | 35 | 671 | 121 | 1251 |
| Neuron differentiation | 1218 | 3 | 17 | 39 | 1277 |
| Axonogenesis | 149 | 270 | 884 | 11 | 1314 |
| Neuron development | 1257 | 1 | 178 | 35 | 1471 |
| Central nervous system development | 742 | 67 | 348 | 320 | 1477 |
| Eating behavior | 1069 | 162 | 104 | 260 | 1595 |
| Cognition | 30 | 146 | 197 | 1286 | 1659 |
| Cell morphogenesis involved in neuron differentiation | 663 | 54 | 975 | 46 | 1738 |
| Generation of neurons | 1726 | 10 | 16 | 23 | 1775 |
| Import into cell | 165 | 394 | 513 | 767 | 1839 |
| Neuron recognition | 56 | 716 | 686 | 443 | 1901 |
| Long-term synaptic potentiation | 282 | 363 | 869 | 408 | 1922 |
| Learning or memory | 54 | 334 | 214 | 1376 | 1978 |
| Anatomical structure morphogenesis | 1163 | 471 | 175 | 169 | 1978 |
Pathway results from missMethyl, using CpG sites associated with prenatal vitamin use in month 1 of pregnancy with P < 0.01 as input (MARBLES cord nCpGs = 4455, MARBLES placenta nCpGs = 9340, EARLI cord nCpGs = 4032, EARLI placenta nCpGs = 3589)