Table 1.

Hypertension Treatment in Nigeria Program implementation package

Component	Start date	Number of sites	Level of intervention	Description as used in the HTN Program	Evaluation
Hypertension Patient Registry and Empanelment	January 2020	60	Health System	Paper-based registration and case report forms facilitate site-based tracking and follow-up of patients, aligns with existing practices for health record management, and are easy to implement. The electronic database facilitates rapid roll up of information in a structured database with built-in quality assurance checks.	Supportive supervision visits include comparison of the site visit logs and the hypertension registry to evaluate completeness of the registry. Bi-weekly data and safety quality reports are generated to review electronic data. Central and on-site training and reinforcement are provided, including the latter during site supervision visits to register all adult hypertensive patients.
Performance and Quality Reporting	December 2020	60	Health Clinic	Monthly performance and quality reports are issued to each participating site to summarize key metrics, aggregated over a rolling 3-month period. Metrics include treatment, control, and retention rates, along with lists of patients for targeted follow-up. Comparisons are made with other sites in the HTN Program.	Data quality audits are conducted during supportive supervision visits to compare data between the paper and electronic case report forms, and correct errant data points. Study team members communicate with sites on a quarterly basis to follow up on performance reports and ascertain if the site has reviewed and understood the report. In interim and final qualitative evaluations, sites will be asked for their feedback on the performance reports.
Simplified Treatment Guideline	December 2020	60	National Policy	A four-step simplified treatment guideline was enacted in the 2019 Nigeria Hypertension Protocol.	Medications data collected in the registry are used to calculate adherence to the four-step protocol by site, and across the program. In interim and final qualitative evaluations, sites will be asked for their feedback on the treatment guideline (appropriateness, feasibility, and adaptation).
Fixed-dose combination	December 2020	60	Health System	Fixed-dose combinations are encouraged in the hypertension treatment guideline when available.	Medications data collected in the registry are used to evaluate administration of fixed-dose or single pill prescriptions by site, and across the program. In interim and final qualitative evaluations, site will be asked for their feedback on fixed-dose combinations (appropriateness, feasibility, and adaptation).
Access to Essential Medicines and Technology	December 2020	60	Health System	Initial hypertension drug supplies were provided to all participating sites to prime the Drug Revolving Fund. During the first year of the intervention phase, work was completed to enact agreements for provision of hypertension medications at reasonable cost. The study team developed protocols, strategies, and training for adding hypertension medications to the Drug Revolving Fund.	Implementation of the Drug Revolving Fund will be evaluated in a separate protocol through RE-AIM outcomes. Early access to medicines in the study is evaluated through treatment rates, as well as stockout and replenishment rates at the participating sites.
Team-Based Care and Community Health Extension Worker Provided Hypertension Management	December 2020	60	Health Worker	Frontline workers (CHEWs, CHOs, pharmacists) have been trained during the control and intervention phase on components of the intervention package. A multidisciplinary team is involved in providing hypertension services in the participating health clinics.	Implementation of team-based care is evaluated through site supervision visits and provider reported experience.
Health Coaching and Home BP Monitoring	September 2022	10	Patient	CHEWs will lead a home-based blood pressure monitoring and health coaching (using motivational interviewing approach) intervention.	Implementation and effectiveness of the home blood pressure monitoring arm will be evaluated through a separate protocol including evaluation of blood pressures and pre- and post-intervention questionnaires.

Abbreviations: CHEW Community health extension worker, CHO Community health officer, HTN Hypertension Treatment in Nigeria