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. 2022 Aug 2;20:360. doi: 10.1186/s12951-022-01541-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Schematic illustration of the functional mechanism of Gel-Exo in facilitating recovery after complete SCI. When Gel-Exo was introduced into SCI treatment, mice with SCI showed OPC differentiation and extensive de novo myelination, which could also be simulated by lentivirus-induced VGF overexpression in the absence of Gel-Exo. Following Gel-Exo transplantation or VGF overexpression, SCI mice displayed increased VGF expression in the spinal cord, extensive regeneration of OLs, and improved motor function. The figure was created with BioRender.com