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. 2022 Aug 2;20:350. doi: 10.1186/s12967-022-03516-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The LINC00665/miR-582-5p/UCHL3 axis affected the radiosensitivity of NSCLC cells by modulating the stability of AhR protein. A, Western blot analysis of AhR protein level in A549 cells treated with sh-LINC00665 or combined with LV-AhR or in PC9 cells treated with LV-LINC00665 or combined with sh-AhR. B, Cell viability in A549 cells treated with sh-LINC00665 or combined with LV-AhR or in PC9 cells treated with LV-LINC00665 or combined with sh-AhR determined by CCK-8 assay. C, Colony formation potential of A549 cells treated with sh-LINC00665 or combined with LV-AhR or in PC9 cells treated with LV-LINC00665 or combined with sh-AhR determined by colony formation assay. D, Cell invasion in A549 cells treated with sh-LINC00665 or combined with LV-AhR or in PC9 cells treated with LV-LINC00665 or combined with sh-AhR determined by Transwell assay. E, Detection of γH2ax fluorescence in irradiation-treated A549 cells treated with sh-LINC00665 or combined with LV-AhR or in PC9 cells treated with LV-LINC00665 or combined with sh-AhR. F, Flow cytometry analysis of cell apoptosis in A549 cells treated with sh-LINC00665 or combined with LV-AhR or in PC9 cells treated with LV-LINC00665 or combined with sh-AhR. G, Flow cytometry analysis of cell cycle distribution in A549 cells treated with sh-LINC00665 or combined with LV-AhR or in PC9 cells treated with LV-LINC00665 or combined with sh-AhR. * p < 0.05 versus the A549 cells treated with sh-LINC00665 + Vector; # p < 0.05 versus the PC9 cells treated with LV-LINC00665 + sh-NC. Each cellular experiment was repeated 3 times