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. 2022 Aug 2;625:53–59. doi: 10.1016/j.bbrc.2022.07.087

Fig. 2.

Fig. 2

SARS-CoV-2 holo-RdRp has robust RNA- and DNA-dependent RNA polymerase activities. (A) RNA-dependent RNA polymerase activity of SARS-CoV-2 holo-RdRp. SARS-CoV-2 holo-RdRp shows a RNA-dependent RNA polymerase activity with either RNA or DNA primer, although RNA primer is more efficient. (B) DNA-dependent RNA-polymerase activity of SARS-CoV-2 holo-RdRp. Unextectedly, SARS-CoV-2 holo-RdRp shows a robust DNA-dependent RNA polymerase activity with a RNA primer. Collectively, SARS-CoV-2 RdRp requires at least one strand of RNA, either in the template or primer, to extend RNA.