FIGURE 5.

Aurora B spatial separation model explains how tension, applied across sister kinetochores, stabilizes kinetochore–MT interactions.^{[ 5 ]} Aurora B is recruited to the inner kinetochore and centromeric nucleosome by INCENP and other CPC components. During syntelic attachment (aberrant kinetochore–MT interactions), Aurora B can reach Dam1C and phosphorylates its components, which destabilized kinetochore attachment to the MT end (top). When biorientation is established, Ndc80Cs are stretched and Aurora B cannot reach Dam1C, which stabilizes kinetochore–MT interactions (bottom). Note that only the CPCs at the inner kinetochore are shown in diagram for simplicity, but CPCs at the centromeric nucleosome (not shown here) should also behave similarly