FIGURE 2.

LSD1 inhibitor protected kidney tissue against IRI in mice. All mice were subjected to ischaemia 30 min and then reperfusion 24 h. (A–B) The effect of LSD1 inhibitor at various concentration (2.5, 5 or 10 mg/kg) on the levels of Cr and BUN in IRI group. (C–F) The effect of LSD1 inhibitor at various concentration on LSD1 and H3K9me2 expression in mice and the quantification. (G) Representative pictures of immunohistochemistry for H3K9me2 (×400; scale bars = 40 μm) (n = 8). The results were expressed as mean ± SEM. *p < 0.05, when compared with the sham group. #p < 0.05, when compared with the IRI group