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Comparison of parsimony score improvement and peak memory requirement of matOptimize and TNT starting from an SARS-CoV-2-based UShER-derived (A) 100K-sample tree, (B) 1M-sample tree and (C) 3M-sample tree. For (C), the peak memory requirement is not shown since TNT did not begin the optimization phase by the time it was terminated after 24 h of execution
