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. 2022 Jul 21;122(17):14066–14084. doi: 10.1021/acs.chemrev.1c01062

Figure 4.

Figure 4

Summary of progress toward SARS-CoV-2 structural characterization. (A) Schematic of the SARS-CoV-2 genome with structurally characterized proteins indicated in full color. Proteins that have not yet been characterized are displayed through homology modeling and are shown as semitransparent images (NSP4/6/12, E protein, M protein). Protein illustrations were generated using Illustrate (ref (34)). (B) The number of X-ray crystallography, cryo-EM, and all SARS-CoV-2 protein structures deposited into the RCSB protein data bank (PDB) over the first 18 months of the COVID-19 pandemic (ref (35)).