Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic parameters of PL-SNP and PL-Lip after intravenous administration in rats (mean ± SD).
| Parameters | Free drug | PL-SNP | PL-Lip |
|---|---|---|---|
| Cmax (μg·mL-1) | 13.39 ± 2.60 | 3.90 ± 0.65 | 51.98 ± 4.78b |
| Tmax (h) | 0.083 | 0.083 | 0.083 |
| t1/2 (h) | 0.333 ± 0.05 | 0.292 ± 0.06 | 1.547 ± 0.53b |
| MRT (h) | 0.332 ± 0.08 | 0.445 ± 0.12a | 2.632 ± 0.41b |
| AUC0-12h (h·μg·mL-1) | 3.712 ± 0.42 | 2.05 ± 0.37 | 27.58 ± 3.93b |
p < .05, compared with free PPM.
p < .01, compared with free PPM.
