Tab. 2: Cell-specific relationships between gene expression effects (either as differentially expressed genes, DEG; or concentration-response genes, CRG) and polycyclic aromatic compound (PAC, 3–7 ring) content of petroleum UVCBs tested in this study.
Both Pearson r and Spearman ϸ are shown with corresponding p-values for each correlation. See Figure 7 for cell type-specific correlation plots.
| Cell type | Type | r | p-value | ρ | p-value |
|---|---|---|---|---|---|
| iCell hepatocytes | DEG | 0.77 | 1.8E-26 | 0.76 | 5.9E-25 |
| CRG | 0.57 | 2.6E-12 | 0.55 | 1.9E-11 | |
| iCell cardiomyocytes | DEG | 0.57 | 1.0E-12 | 0.16 | 0.071 |
| CRG | 0.21 | 0.014 | 0.14 | n.s. | |
| iCell neurons | DEG | 0.39 | 1.4E-05 | 0.07 | n.s. |
| CRG | 0.20 | 0.047 | 0.15 | n.s. | |
| iCell endothelial | DEG | 0.13 | n.s. | 0.06 | n.s. |
| CRG | 0.09 | n.s. | 0.08 | n.s. | |
| MCF7 | DEG | −0.04 | n.s. | 0.26 | 0.005 |
| CRG | −0.04 | n.s. | 0.25 | 0.006 | |
| A375 | DEG | 0.11 | n.s. | 0.08 | n.s. |
| CRG | 0.19 | 0.026 | 0.32 | 2.1E-04 | |
| All cells combined | DEG | 0.34 | 5.9E-21 | 0.24 | 5.2E-11 |
| CRG | 0.16 | 8.9E-06 | 0.23 | 1.4E-10 |