Table 3.
Top 20 differentially expressed proteins in dorsal raphe of PWE versus control
| Gene | Protein | UniProt ID | ANOVA P-value | ANOVA q value | Tukey P-value | Fold change |
|---|---|---|---|---|---|---|
| Increased | ||||||
| PSMB4 | Proteasome subunit beta type-4 | P28070 | 2.01E-05 | 8.82E-03 | 2.86E-04 | 2.05 |
| CNRIP1 | CB1 cannabinoid receptor-interacting protein 1 | Q96F85 | 2.37E-05 | 8.82E-03 | 7.30E-04 | 1.31 |
| PRPH | Peripherin | P41219 | 4.04E-04 | 2.41E-02 | 1.64E-03 | 1.45 |
| NAXE | NAD(P)H-hydrate epimerase | Q8NCW5 | 4.16E-04 | 2.41E-02 | 2.60E-03 | 2.17 |
| PTGR2 | Prostaglandin reductase 2 | Q8N8N7 | 2.66E-03 | 3.61E-02 | 3.02E-03 | 1.81 |
| GSS | Glutathione synthetase | P48637 | 2.88E-03 | 3.63E-02 | 3.11E-03 | 1.72 |
| RCN1 | Reticulocalbin-1 | Q15293 | 1.63E-03 | 3.12E-02 | 3.22E-03 | 1.36 |
| CAST | Calpastatin | P20810 | 2.30E-03 | 3.39E-02 | 3.32E-03 | 2.44 |
| CAPN5 | Calpain-5 | O15484 | 3.42E-03 | 3.63E-02 | 4.10E-03 | 5.12 |
| SBSN | Suprabasin | Q6UWP8 | 6.22E-03 | 4.34E-02 | 4.58E-03 | 2.56 |
| Decreased | ||||||
| ANXA6 | Annexin A6 | P08133 | 3.96E-05 | 9.58E-03 | 3.68E-04 | 1.27 |
| KIF21A | Kinesin-like protein KIF21A | Q7Z4S6 | 5.60E-04 | 2.62E-02 | 8.60E-04 | 1.15 |
| FLII | Protein flightless-1 homologue | Q13045 | 6.13E-05 | 1.19E-02 | 1.25E-03 | 1.21 |
| MX1 | Interferon-induced GTP-binding protein Mx1 | P20591 | 1.77E-04 | 2.10E-02 | 1.33E-03 | 1.55 |
| ARPC2 | Actin-related protein 2/3 complex subunit 2 | O15144 | 6.92E-04 | 2.64E-02 | 1.38E-03 | 1.15 |
| DDX3X | ATP-dependent RNA helicase DDX3X | O00571 | 4.24E-05 | 9.58E-03 | 3.44E-03 | 1.19 |
| LYPLA2 | Acyl-protein thioesterase 2 | O95372 | 3.31E-03 | 3.63E-02 | 4.06E-03 | 1.22 |
| TACO1 | Translational activator of cytochrome c oxidase 1 | Q9BSH4 | 3.58E-03 | 3.65E-02 | 4.32E-03 | 1.40 |
| RPS3 | 40S ribosomal protein S3 | P23396 | 2.60E-05 | 8.82E-03 | 5.29E-03 | 1.18 |
| EIF4A1 | Eukaryotic initiation factor 4A-I | P60842 | 1.86E-04 | 2.10E-02 | 5.59E-03 | 1.20 |