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. 2022 Jul 19;15:892820. doi: 10.3389/fnmol.2022.892820

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Copyright © 2022 Maksemous, Blayney, Sutherland, Smith, Lea, Tran, Ibrahim, McArthur, Haupt, Cader, Finol-Urdaneta, Adams and Griffiths.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Voltage dependence of activation of Cav3.3 WT and HM-associated variants. (A) Normalized conductance (G/G_max) vs. voltage relationships for Cav3.3 and HM variants. Representative current families are included as insets. Dotted lines are drawn at G/Gmax = 0.5 to highlight the voltage of half-maximal activation (activation V_0.5). (B) SuperPlots of activation V_0.5 and slope [d(x)]. Symbols represent determination made from cells transfected on the same day (i.e., biological replicates). 0.001 < p < 0.01 (**), 0.01 < p 0.05 (*).