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. Author manuscript; available in PMC: 2023 Jul 7.
Published in final edited form as: Cell Stem Cell. 2022 Jul 7;29(7):1135–1153.e8. doi: 10.1016/j.stem.2022.06.007

Fig 1. Characterization of DS hiPSC-derived PMPs.

Fig 1.

(A) Schematic representation of the generation and characterization of PMPs. This drawing was created using BioRender.com.

(B) Representative images of CD235+, CD43+, Ki67+ cells, and FISH analysis in PMPs. Scale bars: 20 μm,10 μm, and 5 μm.

(C) Quantification of CD235+, CD43+, CD235+/CD43+, and Ki67+ PMPs derived from the three pairs of Cont and DS hiPSC lines (n=3).

(D) The heatmap showing all DEGs between Cont and DS PMPs.

(E-F) GO analyses of the upregulated and downregulated DEGs in the PMPs.

(G) A volcano plot illustrating downregulated (blue) and upregulated (red) DEGs in PMPs.