Table 3.
Primary outcome findings for Wisepill-assessed adherence (percent of days that Wisepill was opened on a 30-day monthly basis)
| Time | Education only | REACH intervention | Condition Differences | |||||
|---|---|---|---|---|---|---|---|---|
| Mean % Monthly Adherence (SE) (n = 45) | Change from baseline (SE) | Within Education change from baseline p value | Mean % MonthlyAdherence (SE) (n = 43) | Change from baseline (SE) | Within REACH change from baseline p value | Between-condition difference in change from baseline (SE) | Between-condition difference in change from baseline p value | |
| Baseline | 95.17 (3.38) | 95.31 (3.46) | ||||||
| Month 1 | 87.79 (3.39) | –7.11 (3.41) | .017 | 96.32 (3.46) | 1.01 (1.45) | .506 | 8.12 (3.71) | .027 |
| Month 2 | 86.67 (3.39) | –8.23 (3.26) | .004 | 94.12 (3.43) | –1.02 (2.16) | .641 | 7.21 (3.92) | .131 |
| Month 3 | 88.49 (3.39) | –6.41 (3.50) | .035 | 89.85 (3.43) | –5.29 (3.83) | .125 | 1.22 (5.24) | .889 |
| Month 4 | 87.18 (3.39) | –7.72 (3.59) | .013 | 82.02 (3.43) | –13.12 (4.19) | <.001 | –5.40 (5.61) | .423 |
| Month 5 | 84.46 (3.41) | –10.66 (4.17) | .003 | 81.31 (3.46) | –13.97 (4.97) | .001 | –3.30 (6.57) | .669 |
| Month 6 | 82.77 (3.41) | –12.24 (4.35) | .001 | 80.28 (3.49) | –14.44 (4.70) | <.001 | –2.20 (6.50) | .757 |
Note: Controlled for AET type and AET side effects (see Methods). However, neither was associated with adherence in these models; p-values >.50
Change from baseline and difference in change from baseline were obtained as average marginal effects, averaged over covariates.