1. Prevented fractions (PF) for caries incremental data.

Comparison (number)	Increment (Study)	PF (95% CI)	Notes
Adults
Xylitol lozenges versus control lozenges (1.1)	33‐month caries increment (Bader 2013)	0.08 (–0.03 to 0.20)	8% reduction in caries in test group
Children
Xylitol lozenges versus no treatment (2.1)	4 year caries increment (Lenkkeri 2012)	‐0.10 (‐0.59 to 0.39)	10% increase in caries in test group compared to control
Xylitol topical oral syrup versus control syrup (3.1)	Caries in primary teeth over 1 year follow‐up (Milgrom 2009)	0.58 (0.33 to 0.83)	58% reduction in caries in test group
Xylitol sucking tablets versus no treatment (4.1)	2 year caries increment (Oscarson 2006)	0.53 (0.001 to 1.04)	53% reduction in caries in test group
Xylitol plus fluoride toothpaste versus fluoride toothpaste (5.1)	2.5 to 3 year caries increment (Sintes 1995)	0.12 (0.06 to 0.18)	12% reduction in caries in test group
	2.5 to 3 year caries increment (Sintes 2002)	0.14 (0.05 to 0.23)	14% reduction in caries in test group

CI = confidence interval