Table 1. Interaction Paxlovid™ with different statins according to Pfizer [17].

Statin	Clinical comments	Recommendation
Lovastatin	Highly dependent on CYP3A metabolism	Contraindicated
Simvastatin	Highly dependent on CYP3A metabolism	Contraindicated
Rosuvastatin	Less dependent on CYP3A metabolism	Use the lowest possible dose
Atorvastatin	Less dependent on CYP3A metabolism	Use the lowest possible dose
Pravastatin	Metabolism is not dependent on CYP3A metabolism	Recommended
Fluvastatin	Metabolism is not dependent on CYP3A metabolism	Recommended