Figure 3.

Causal mediation analysis results for the model investigating the relationships among amyloid group (A) and tau in the EC and the ITG in BLSA (left) and ADNI (right). The effect of amyloid on ITG tau is mediated by EC tau. Arrow from A to EC tau indicates the linear regression coefficient, and the gray and red arrows from EC tau to ITG tau indicate the linear regression coefficients for the amyloid negative and positive groups, respectively. Both the mediator and the outcome models were adjusted for age, sex, APOE ε4 positivity, years of education, and 10-year cardiovascular disease risk. ***P < 0.001, **P < 0.01, *P < 0.05.