Skip to main content
. Author manuscript; available in PMC: 2022 Aug 2.
Published in final edited form as: Neuropharmacology. 2019 Mar 14;151:189–194. doi: 10.1016/j.neuropharm.2019.03.019

Figure 2.

Figure 2.

Dose-dependent heroin self-administration in mice of both sexes. Left panel: Increased heroin self-administration at 30 μg/kg/infusion in female mice compared with male mice. Center panel: Male and female mice did not differn in heroin self-administration at 60 μg/kg/infusion. Right panel: Female mice change their heroin self-administration in function of the dose, whereas the male mice did not. The graph shows the average of the last three sessions at the 30 μg/kg/infusion dose shown in the left panel compared with the average of the last three sessions at the 60 μg/kg/infusion dose shown in the center panel. Note: only the mice assigned to the ShA group were used (1 h sessions for both doses). *p<0.05, **p<0.01, ***p<0.001.