Table 1.

Relevant variables to be registered during the study period

Baseline
Demographics, comorbidities, APACHE-II score, SOFA score
Sepsis source, treatment, adequacy of treatment, time from shock initiation to first antibiotics
Pre-ICU resuscitation administered fluid and fluid balance, AKI-KDIGO criteria(19,20)
Hemodynamics: HR, SAP, MAP, DAP, CVP, NE dose
Perfusion variables: lactate, ScvO2, delta pCO2(v-a), hemoglobin, CRT, mottling score
Evolution
SOFA score at 8, 24, 48 and 72 hours and at 4, 5 and 7 days
AKI criteria at 8, 24, 48 and 72 hours
Hemodynamics hourly up to 6 hours
Fluid administration and balance at 6, 24, 48 and 72 hours
Complete perfusion assessment at 6, 24, 48 and 72 hours
Register of vasoactive drugs and dobutamine/milrinone use
Register of CCE
Register of FR status and techniques
Register of MV and RRT techniques
Adjuvant therapies: high-volume hemofiltration, use of vasopressin, epinephrine, others
Follow-up until 28 days for use of MV, RRT and vasopressors
All-cause mortality at hospital discharge and at 28 and 90 days
Cause of death

APACHE II - Acute Physiology And Chronic Health Evaluation II; SOFA - Sequential organ failure Assessment; ICU - intensive care unit; AKI - acute kidney injury; KDIGO - Kidney Disease: Improving Global Outcomes; HR - heart rate; SAP - systolic arterial pressure; MAP - mean arterial pressure; DAP - diastolic arterial pressure; CVP - central venous pressure; NE - norepinephrine; ScvO2 - central venous oxygen saturation; delta pCO2(v-a): difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure; CRT - capillary refill time; CCE - critical care echocardiography; FR - fluid responsiveness; MV - mechanical ventilation; RRT - renal replacement therapy.