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. 2022 Mar 17;21(13):1391–1405. doi: 10.1080/15384101.2022.2051971

Figure 4.

Figure 4.

HSP90B knockdown could reverse the tumor-promoting effect of RP3-326I13.1. (a, b)HSP90B knockdown successfully reversed the pro-proliferative effect of RP3-326I13.1 in both groups with and without DDP treatment. (c, d) HSP90B knockdown reversed the pro-invasive effect of RP3-326I13.1 in both groups with and without DDP treatment .(e, f) Knockout of HSP90B reversed the anti-apoptotic ability of RP3-326I13.1 and produced more apoptotic cells in the two groups with or without DDP intervention. Invasion experiments were observed using 200 times under the mirror. ** P < 0.01, *** P < 0.001, **** P < 0.0001, # P < 0.05, ### P < 0.001, #### P < 0.0001.