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. 2022 Mar 17;21(13):1391–1405. doi: 10.1080/15384101.2022.2051971

Figure 5.

Figure 5.

MMP13 served as a downstream mRNA of RP3-326I13.1. (a) The heat map showed the differential mRNA expression in RP3-326I13.1 overexpression and knockdown cells of LAD. (b-i) RT-qPCR was used to verify the differentially expressed mRNA in the sequencing results, including MMP13, CP, ICAM1, CDK18, PARP14, OAS3, CXCL8 and PLEKHA4. (j, k) It showed the proliferation ability of MMP13 overexpression (j) and knockdown (k) with or without DDP treatment by CCK-8 assays. ns: no significance, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.