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. 2022 Mar 17;21(13):1391–1405. doi: 10.1080/15384101.2022.2051971

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Figure 6. — RP3-326I13.1 promoted tumor growth and decreased the sensitivity to cisplatin chemotherapy in nude mice. (a) Representative images of nude mice xenografts after injection of RP3-326I13.1 overexpression or knockdown cells and treatment with DDP (including control+DDP, OE-NC+DDP, OE-RP3-326I13.1+ DDP, sh-NC+DDP, sh-RP3-326I13.1+ DDP) for 28 days. (b) The volume of xenografted tumors in each group of nude mice. The tumor volumes were measured every 7 days (tumor volume = length×width²/2). (c) Representative images of tumor cell necrosis in xenografted tumors in each group were analyzed by HE staining. (d, e) The mRNA and protein expression levels of HSP90B and MMP13 in the sh-RP3-326I13.1+ DDP group were lower than those in the sh-NC+DDP group, while the mRNA and protein expression levels of HSP90B and MMP13 in the OE-RP3-326I13.1+ DDP group It is higher than the OE-NC+DDP group. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.