Table 2.

Recommendations for maximum population-based cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy

Study, year	Effluent rates (L/h)a	CVVH	CVVHD or CVVHDF
Trotman et al. (2005) [176]	Not available	1–2 g q12h	2 g q12h
Heintz et al. (2009) [177]	Not available	1–2 g q12h	1 g q8h or 2 g q12h
Scheetz et al. (2006) [68]	≤1	2g q24h	2 g q24h
	2	2g q12h	2 g q12h
	3	2g q8h	2 g q8h
Carlier et al. (2015) [67]	≤1	1 g q8h	1 g q8h
	2	2 g q8h	2 g q8h or 1 g q6h
	3	2 g q8h	2 g q8h or 1 g q6h
Chaijamorn et al. 2018)b [178]	≤1	1.75 g LD then 1.5 g q8h	1.75 g LD then 1.5 g q8h
	2	2 g LD then 1.5 g q8h	1.75 g q8h
	3	2 g LD then 1.5-1.75 g q8h	2 g q8h
Philpott et al. (2019) [179]	≤1	Not available	Not available
	2	2 g q8h as a 4-h infusion	2 g q8h as a 4-h infusion
	3	2 g q8h as a 4-h infusion	2 g q8h as a 4-h infusion

CVVH continuous venovenous hemofiltration, CVVHD continuous venovenous hemodialysis, CVVHDF , h hour, LD loading dose, q6h every 6 h, q8h every 8 h, q12h every 12 h, q24h every 24 h

^aEffluent rates in mL/kg/h were converted to L/h

^bDosing for minimum inhibitory concentrations up to 8 μg/mL