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. 2022 Jul 26;2022:4061713. doi: 10.1155/2022/4061713

Figure 9.

Figure 9

Activation of the Hh signaling attenuated the effects of AHCY silencing on inflammation and oxidative stress in vitro. (a, b) Effect of SAG on the levels of IL-1β and IL-6 regulated by AHCY knockdown in the supernatant of SW620 cells were examined by ELISA. (c–f) Western blot was used to examine the effect of SAG on the expression of COX-2 and iNOS regulated by AHCY knockdown in SW620 cells, respectively. Representative blots are shown with densitometry (n = 3). (g) Effect of SAG on the level of MDA regulated by AHCY knockdown in SW620 cells. (h) Effect of SAG on the level of GSH regulated by AHCY knockdown in SW620 cells. (i) Effect of SAG on the activity of SOD regulated by AHCY knockdown in SW620 cells. Data are expressed as the mean ± SD (n = 3). ∗p < 0.05 and∗∗p < 0.01 versus the control group; #p < 0.05 and##p < 0.01 versus the control group; &p < 0.05 and&&p < 0.01 versus the AHCY shRNA group.