Table 2.
Technical aspects of dynamic CZT-SPECT studies included in meta-analysis
| Authors | Index test | Mean total effective dose (mSv) | Rest dose (MBq) | Stress dose (MBq) | Stress injection protocol | CZT cut-off value |
|---|---|---|---|---|---|---|
| Agostini et al.10 | Rest/stress Tc MPI | 8.73 | 3MBq/kg | 9MBq/kg | Regadenoson (400 μg) | MFR < 2.1 |
| Bouallègue et al.15 | Rest/stress Tc MPI | 8.4 | 220-280 | 645-730 | Dipyridamole 0.75 mg/kg | MFR < 2 |
| Han et al.16 | Stress Tl/rest Tc MPI | 9.13 | 222–370 | 44–66 | Adenosine (140 mcg/kg/min) | MFR ≤ 2.0 |
| Li et al.17 | Rest/stress MIBI | N.A. | 555 | 925 | Adenosine (140 mcg/kg/min) | MFR < 2.12 |
| Miyagawa et al.12 | Stress/rest Tc MPI | 6.34 | 3MBq/kg | 9 MBq/kg | Adenosine (160 mcg/kg/min) | MFR < 1.3 |
| Nkoulou et al.18 | Stress/rest Tc MPI | N.A. | ~1000 | 330±33 | Adenosine (140 mcg/kg/min) | MFR <1.26 |
| Shiraishi et al.19 | Stress/rest Tl MPI | 15.5 | 50–60 | 50–60 | Adenosine 0.120 mg/kg/min) | MFR ≤ 1.5 |
| Shiraishi et al.20 | Stress/rest Tl MPI | 15.5 | 50–60 | 50–60 | Adenosine 0.120 mg/kg/min) | MFR < 2.66 |
| Zavadovsky et al.11 | Rest/stress Tc MPI | 8.02 | 3MBq/kg | 9MBq/kg | Adenosine (140 mcg/kg/min) | MFR ≤ 1.48 |
| Authors | CZT-SPECT | Comparator | Definition of comparator cut-off value | Time between tests | Analysis Software |
|---|---|---|---|---|---|
| Agostini et al.10 | D-SPECT | 15O-Water PET | MFR < 2 | 30 d |
Corridor4DM (INVIA Medical Imaging Solutions) |
| Bouallègue et al.15 | Discovery NM 530c | FFR | FFR ≤ 0.8 | 4 w | In-house software |
| Han et al.16 | Discovery NM 530c | FFR | FFR ≤ 0.8 | 90 d |
Corridor4DM (INVIA Medical Imaging Solutions) |
| Li et al.17 | D-SPECT | FFR | FFR < 0.8 | 3 days | Corridor4DM (INVIA Medical Imaging Solutions) |
| Miyagawa et al.12 | Discovery NM 530c | FFR | FFR < 0.8 | 2 m | NA |
| Nkoulou et al.18 | Discovery NM 530c | 13NH3-ammonia PET | MFR < 2.0 | 12 weeks | PMOD software package (version 3.1; PMOD Technologies Ltd.) |
| Shiraishi et al.19 | Discovery NM 530c | FFR | FFR < 0.8 | 30 d | In-house software |
| Shiraishi et al.20 | Discovery NM 530c | FFR | FFR < 0.8 | 90 d | AZE Virtual Place Hayabusa (AZE, Ltd., Tokyo, Japan) |
| Zavadovsky et al.11 | Discovery NM 570c | FFR | FFR ≤ 0.8 | 7 d |
Corridor4DM (INVIA Medical Imaging Solutions) |
CZT-SPECT, cadmium-zinc-telluride single-photon emission tomography; FFR, fractional flow reserve; MFR, myocardial flow rate; MPI, myocardial perfusion imaging; NA, not available; PET, positron emission tomography; Tc, technetium-99m; Tl, Thallium-201