Table 3.
Significant genes shared between type 2 diabetes/glycaemic traits and PCOS identified from the TWAS using gene expression across 48 GTEx tissues
| Trait pair | CHR | Gene | Trait | PCOS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BEST.GWAS.ID | Tissue | TWAS.Z | FDR | BEST.GWAS.ID | Tissue | TWAS.Z | FDR | |||
| T2DM and PCOS | 11 | ARL14EP | rs4922556 | Adipose subcutaneous, adrenal gland, artery aorta, artery coronary, artery tibial, brain caudate basal ganglia, brain cerebellum, breast mammary tissue, colon sigmoid, colon transverse, oesophagus gastroesophageal junction, oesophagus mucosa, oesophagus muscularis, heart atrial appendage, heart left ventricle, lung, nerve tibial, ovary, pituitary, skin not sun exposed suprapubic, skin sun exposed lower leg, stomach, thyroid, vagina | –2.83 to –3.89 | 4.84×10−2 to 2.73×10−3 | rs10835649 | Artery aorta, artery tibial, thyroid | 4.36 to 5.24 | 1.49×10−3 to 4.99×10−2 |
| T2DMadjBMI and PCOS | 11 | ARL14EP | rs4922556 | Artery aorta, thyroid | –3.16 to –3.14 | 3.52×10−2 to 3.71×10−2 | rs10835649 | Artery aorta, artery tibial, thyroid | 4.36 to 5.24 | 1.49×10−3 to 4.99×10−2 |
| 18 | SERPINB8 | rs4508511 | Nerve tibial, stomach | 3.08 to 3.53 | 1.12×10−2 to 4.55×10−2 | rs2162352 | Stomach | –4.17 | 4.48×10−2 | |
BEST.GWAS.ID, rsID of the most significant GWAS SNP in locus; CHR, chromosome; T2DM, type 2 diabetes mellitus; TWAS.Z, TWAS Z-score