Table 1.

Summary of sequenced donor data and numbers of sequenced cells

Characteristic	Donor ID
	R253	R282	R317
Age (years)	57	57	54
Sex	Male	Male	Male
Height (m)	1.78	1.86	1.8
Weight (kg)	81.1	91.5	85.5
BMI (kg/m2)	25.5	26.4	26.4
HbA1c (mmol/mol)	31.1	43.2	32.2
HbA1c (%)	5.0	6.0	5.1
Diabetes	None	None	None
No. of sequenced cellsa	17,645	33,770	49,033
Average reads/cell	37,911	21,447	14,841
No. of cells in Fig. 1bb	12,753	21,372	34,525

Data show a high degree of similarity between donor biometrics. Further data on donor islets are available at Alberta Diabetes Institute Islet Core Facility (https://www.epicore.ualberta.ca/IsletCore/) and in the Human Islets Checklist in the ESM

^aThe number of cells per donor that were sequenced, prior to the filtering and quality control

^bThe number of cells per donor that were sequenced and passed all filtering and quality control thresholds