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. 2022 Apr 28;127(3):474–487. doi: 10.1038/s41416-022-01825-3

Table 1.

Correlation between HIF-1α expression and clinicopathological characteristics in 69 oesophageal squamous cell carcinoma patients.

HIF-1α expression level
High (45) Low (24) P valuea
Gender 0.275
 Male 37 17
 Female 8 7
Age (years)
 >68 23 11 0.676
 ≤68 22 13
T stage 0.015b
 1 8 13
 2 8 1
 3 26 9
 4 3 1
N stage
 N0 20 8 0.023b
 N1 8 12
 N2 11 4
 N3 6 0
Pathological stage 0.321
 I 5 7
 II 17 7
 III 17 8
 IV 6 2
Infiltrative growth (INF) 0.175
 a 2 4
 b 41 18
 c 2 2
Lymphatic invasion 0.280
 Positive 23 9
 Negative 22 15
Vascular invasion 0.031b
 Positive 37 14
 Negative 8 10
β-catenin expression 0.003b
 High 22 3
 Low 23 21
TCF4/TCF7L2 expression 0.109
 High 26 9
 Low 19 15

aStatistical significance is determined by the Chi-square test or Fisher’s exact test.

bThe bold figures in the table indicate that the P value is statistically significant.