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. 2022 Jun 7;27(4):397–415. doi: 10.1007/s12192-022-01281-1

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Fig. 6 — The canonical interaction of Hsp70s with JDPs is mediated by three major contacts within the J-domain, as shown in a co-crystal structure of the E. coli DnaK/DnaJ system (PDB 5NRO). The conservation of those residues across Hsp70 orthologs in E. coli (DnaJ), yeast (Ydj1 and Sis1), and humans (DnaJA1 and DnaJB1) is shown from a CLUSTALW multiple sequence alignment