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. 2022 Jun 7;27(4):397–415. doi: 10.1007/s12192-022-01281-1

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Fig. 7 — JDPs and Hsp70 interact using multiple sites. (A) The conserved J-domain binds to the NBD and linker of Hsp70s (see Fig. 6). In addition, Class B JDPs also bind to the EEVD motif present in cytoplasmic Hsp70s. (B) Co-crystal structure of an Hsp70 derived EEVD motif peptide (gray) bound to CTDI of human DnaJB1 (blue; PDB 3AGY), highlighting the key residues responsible for complex formation