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. 2022 Apr 20;127(3):577–586. doi: 10.1038/s41416-022-01815-5

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — BRD3-NUT 10326 tumour sections after treatment with 2 mg/kg BI 894999, 5 mg/kg or 10 mg/kg CCS1477 and the combination of both. Upper row: IHC staining for proliferation marker Ki67. Middle row: Pseudocolour staining based on human mitrochondria stain. Red = tumour, green = stroma. Lower row: IHC staining for NUT protein. Strong reduction of tumour viable area and complete absence of proliferating tumour cells with combination treatment. Effect of BET monotherapy on tumour cells may be underestimated by in vivo tumour measurement.