Table 1.

Bone histomorphometric analysis in Becn1 WT and cKO mice.

	6 months (femurs)				6 months (vertebrae, L5)
	male		female		male		female
	WT (n = 4)	cKO (n = 7)	WT (n = 5)	cKO (n = 5)	WT (n = 4)	cKO (n = 7)	WT (n = 5)	cKO (n = 5)
BV/TV (%)	16.37 ± 2.02	11.93 ± 1.66 **	4.31 ± 1.74	3.56 ± 2.34	25.85 ± 4.28	20.68 ± 2.77 *	N.A	N.A
Tb.N (mm-1)	4.45± 0.56	2.99 ± 0.44 **	1.71 ± 0.47	1.08 ± 0.64	6.63 ± 0.38	6.14 ± 0.73	N.A	N.A
Tb.Th (μm)	36.86 ± 2.61	39.95 ± 2.67	24.86 ± 2.68	32.39 ± 2.5 **	38.83 ± 4.78	33.66 ± 1.74 *	N.A	N.A
Tb.Sp (μm)	190.74 ± 31.25	299.1 ± 42.72 **	602.6 ± 191.75	1264.35 ±914.37	112.35 ± 13.18	131.05 ± 18.76	N.A	N.A
Ob.S/BS (%)	2.77 ± 2.05	3.46 ± 2.91	7.93 ± 5.6	3.69± 4.26	6.48 ± 4.38	3.93 ± 2.26	N.A	N.A
N.Ob/BS (mm-1)	2.34 ± 1.64	3.17 ± 2.42	5.76 ± 4.23	3.3 ± 2.86	4.84 ± 2.74	3.27 ± 1.6	N.A	N.A
OS/BS (%)	7.25 ± 5.05	4.18 ± 2.77	6.03 ± 3.68	6.22 ± 8.92	8.2 ± 3.77	2.94 ± 0.87 **	N.A	N.A
Oc.S/BS (%)	1.73 ± 0.61	1.51 ± 0.92	1.56 ± 0.97	0 **	1.15 ± 0.26	2.34 ± 1.54	N.A	N.A
N.Oc/BS (mm-1)	0.68 ± 0.25	0.62 ± 0.36	0.42 ± 0.07	0 ***	0.4 ± 0.09	0.87 ± 0.56	N.A	N.A
ES/BS (%)	3.04 ± 0.88	2.69 ± 1.78	2.74 ± 1.93	0 *	1.95 ± 0.73	4.15 ± 2.99	N.A	N.A
MS/BS (%)	5.66 ± 4.31	18.7 ± 6.34 *	16.38 ± 6.52	13.67 ± 7.32	4.4 ± 3.9	7.72 ± 1.77	N.A	N.A
MAR (μm day-1)	0.48 ± 0.19	0.74 ± 0.34	0.99 ± 0.31	0.83 ± 0.24	0.54 ± 0.11	0.65 ± 0.04	N.A	N.A
BFR/BV (% Year-1)	61.7 ± 63.2	255.09 ± 96.3 *	522.76 ± 360.57	237.75 ± 118.62	56.58 ± 61.94	109.93 ± 27.62	N.A	N.A

Male Becn1 WT versus male Becn1 cKO, and female Becn1 WT versus female Becn1 cKO; Student’s t test.

^*p <0.05

^**p < 0.01

^***p < 0.001