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2019 WHO Classification of Digestive System Neuroendocrine Tumors15
| Differentiation | Grade | Mitotic Index (Number of Mitoses/2 mm2) | Ki-67 Index | |
|---|---|---|---|---|
| NET, G1 | Well differentiated | Low | <2 | <3% |
| NET, G2 | Well differentiated | Intermediate | 2–20 | 3–20% |
| NET, G3 | Well differentiated | High | >20 | >20% |
| NEC | Poorly differentiated | High | >20 | >20% |
Abbreviations: NET, neuroendocrine tumor; NEC, neuroendocrine cancer; Ki-67, cell proliferation index.
