Table 3.

Univariate linear regression for resting energy expenditure quotient.

	Standardized beta	95% CI		P-value
		Lower	Upper
Partial or gross total resection	−0.12	−0.21	−0.02	0.022*
Progression or recurrence of the tumor	−0.10	−0.19	−0.01	0.030*
Severe clinical hypothalamic dysfunctiona	−0.23	−0.33	−0.12	<0.001*
Posterior hypothalamic damageb at time of diagnosis	−0.10	−0.19	−0.01	0.027*
Posterior hypothalamic damage on MRI at time of REE measurement	−0.13	−0.21	−0.04	0.004*
Severe mammillary body damagec	−0.12	−0.21	−0.04	0.007*
Pan hypopituitarism with diabetes insipidus	−0.9	−0.17	−0.00	0.050*

Resting energy expenditure quotient: Measured resting energy expenditure divided by predicted resting energy expenditure (calculated by Schofield equation). Diabetes insipidus at follow-up, central precocious puberty at follow-up, age at diagnosis, age at follow-up, BMI SDS at follow-up, fat-mass percentage (n  = 54), hydrocephalus at diagnosis, tumor size (n  = 63), severe mammillary body damage at diagnosis (n  = 65), radiotherapy, and chemotherapy were not significantly associated with mREE/pREE quotient.

^aSevere clinical hypothalamic dysfunction: Presence of obesity (>+3.0 BMI SDS) or extreme weight gain (>+2.0 BMI SDS) with (severe) hyperphagia and presence of other clinical manifestations, such as impaired thirst, rage behavior, or disturbances of thermoregulation, memory, and sleep-wake pattern. ^bPosterior hypothalamic damage graded with Muller: hypothalamic involvement/lesion of the anterior and/or solely posterior hypothalamic area, i.e. involving the area beyond mammillary bodies. ^cSevere mammillary body damage: severe involvement or damage (unrecognizable structures or both sided damaged) of the mammillary bodies. ^*Statistically significant.