Table 4.

Multivariate linear regression for resting energy expenditure quotient.

	Standardized beta	95% CI		P-value
		Lower	Upper
Progression or recurrence of the tumor	−0.09	−0.17	−0.002	0.046*
Severe clinical hypothalamic dysfunctiona	−0.12	−0.23	−0.012	0.030*
Posterior hypothalamic damageb on MRI at time of REE measurement	−0.05	−0.16	0.048	0.293
Severe mammillary body damagec	−0.03	−0.14	0.073	0.546
Pan hypopituitarism with diabetes insipidus	−0.09	−0.18	−0.009	0.030*

Resting energy expenditure quotient: Measured resting energy expenditure divided by predicted resting energy expenditure (calculated by Schofield equation).

^aSevere clinical hypothalamic dysfunction: Presence of obesity (>+3.0 BMI SDS) or extreme weight gain (>+2.0 BMI SDS) with (severe) hyperphagia and presence of other clinical manifestations, such as impaired thirst, rage behavior, or disturbances of thermoregulation, memory, and sleep-wake pattern. ^bPosterior hypothalamic damage graded with Muller: hypothalamic involvement/lesion of the anterior and/or solely posterior hypothalamic area, i.e. involving the area beyond mammillary bodies. ^cSevere mammillary body damage: severe involvement or damage (unrecognizable structures or both sided damaged) of the mammillary bodies. ^*Statistically significant.