. 2022 Jun 30;3(3):R121–R146. doi: 10.1530/RAF-22-0005
This work is licensed under a Table 4.
Examples of interspecific somatic cell nuclear transfer (iSCNT) of mammalian species including oocyte and nuclear donor. The International Union for the Conservation of Nature (IUCN) red list status of the nucleus donor species is also included. Many of the resulting offspring did not show long-term survival, and outcome is noted where available.
| Oocyte donor | Nucleus donor | IUCN red list status of nucleus donor | Outcome | Reference |
|---|---|---|---|---|
| Domestic cat (Felis catus) | African wild cat (Felis silvestris lybica) | Least concern (subspecies unclear) | 17 kittens, 2 survived long term | Gómez et al. (2004) |
| Domestic cat (F. catus) | Sand cat (Felis margarita) | Least concern | 1 of 14 kittens born survived 2 months | Gómez et al. (2008) |
| Domestic cat (F. catus) | Cheetah (Acinonyx jubatus) | Vulnerable | Incomplete nuclear reprogramming | Moro et al. (2015) |
| Domestic cat (F. catus) | Kodkod (Leopardus guigna) | Vulnerable | Embryos only developed to the morula stage | Veraguas et al. (2020) |
| Domestic cow (Bos taurus) | Banteng (Bos javanicus) | Endangered | 2 calves, 1 survived long term | Janssen et al. (2004) |
| Domestic sheep (Ovis aries) | Mouflon (Ovis orientalis musimon) | Near threatened | 1 lamb, ‘apparently normal’ | Loi et al. (2001) |
| Domestic sheep (O. aries) | Esfahan mouflon (Ovis orientalis isphahanica) | Vulnerable | 2 lambs, both died shortly after birth | Hajian et al. (2011) |
| Spanish Ibex (Capra pyrenaica) | Pyrenian ibex, Bucardo (Capra pyrenaica pyrenaica) | Least concern (subspecies extinct) | 1 kid, died shortly after birth | Folch et al. (2009) |
| Dromedary (Camelus dromadarius) | Bactrian camel (Camelus bactrianus) | Critically endangered | 1 calf, died on day 7 post-partum | Wani et al. (2017) |
| Domestic dog (Canis familiaris) | Grey wolf (Canis lupus) | Least concern | 4 pups, 3 survived long term | Oh et al. (2008) |
| Domestic dog (C. familiaris) | Coyote (Canis latrans) | Least concern | 8 pups, all viable | Hwang et al. (2012) |
| Domestic ferret (Mustela furo) | Black-footed ferret (Mustela nigripes) | Endangered | 1 pup, survived long term | Sandler et al. (2021) |
| Macaque monkey (Macaca mulatta) | Crab-eating macaque (Macaca fascicularis) | Vulnerable | 2 young, healthy | Liu et al. (2018) |